ABSTRACT
Objective: To observe the protective effect of Curcuma Longa in Nitro-Methane Sulfonamide induced hepatotoxicity
Study design: Experimental Case Control Study
Place and duration: Departments of Physiology and Postgraduate Research Lab of ISRA University Hyderabad, from 1st June 2012 to 31st December 2012
Methodology: 40 male albino Wistar rats were equally divided into four groups of 10 each. Group A used as the control group and was fed the normal rat chow for 09 days. Group B was fed with Nitro-Methane sulfonamide for 09 days followed by Curcuma Longa for next 09 days. Group C was given Curcuma Longa for 09 days followed by Nitro-Methanesulfonamide for next 09 days. Group D was given Nitro-Methane sulfonamide in combination with Curcuma Longa for 09 days. After 24 hours of feeding, blood samples from groups A and D were taken from dorsal vein in the tail of rats for biochemical analysis of serum levels of ALT, AST, ALP and a-GT at days 01 and 09 and for groups B and C blood samples were collected at day 01, day 09 and day 18
Results: The analysis showed that prevention from the Nitro-Methane sulfonamide induced hepatotoxicity by the Curcuma Longa administration was observed after 18 days with a p value < 0.012, and Pearson's correlation for regression at - 0.06 and -0.07
Conclusion: The results have clearly proven that Curcuma Longa in powdered form as used in the daily diet in our part of world acts as a homeostatic booster against a huge variety of stressors especially "over the counter" drug induced hepatic stresses
ABSTRACT
Objectives: To find out the simple, economical and diagnostic test for detecting Acute Myocardial Infraction [AMI] at distant areas
Study Design: Cross sectional study
PLACE AND DURATION: Six months
Methodology: 03 ml of blood sample was collected from 140 patients presenting to the Emergency /Coronary Care Units of hospitals viz Isra University Hyderabad, Red Crescent Hyderabad and Civil Hospital Hyderabad. The slides were prepared and white blood cells were counted microscopically at Post Graduate laboratory of Isra University Hyderabad
Results: In present study Neutrophil/Lymphocyte [N/L] ratio was observed and compared in both subjects [cardiac and non-cardiac]
The N/L ratio was found to be normal in non-cardiac patients but was significantly raised in patients with myocardial infarction
Especially in Acute Myocardial Infarction with ST segment elevation [AMI-STE] in comparison to Acute Myocardial Infarction with non STsegment elevation [AMI-NSTE] was also observed [p< 0.001]
Conclusion: The N/L ratio was significantly raised in patients with AMI suggesting an additional diagnostic parameter for AMI at primary health care units
ABSTRACT
Objectives: To observe and assess the efficacy of Aloe Vera extract on skin wound healing
Study Design: Analytic and experimental
Place And Duration: Departments of Physiology, Pathology and Postgraduate Research Lab of ISRA University Hyderabad, from June 2011 to December 2011
Methodology: 20 millimeter long cuts were made over the back of 18 rabbits. The rabbits were divided into three groups A,B and C, each comprising 06 numbers, and treated daily for 11 days with Xylo Aid, mixture of Xylo Aid and Alo Vera extract and Aloe Vera extract, and marked blue, black and green respectively. Taking the operation day as zero, 3 rabbits were sacrificed after 24 hours and then alternatively till the llth post-operative day. The entire wound area along with 4-5 mm of the surrounding skin was excised and fixated in 10% formaldehyde, after processing sections were made stained with Hand E and observed under microscope, the fibroblasts were counted to see the quality of wound healing, keeping group A as control the results were tabulated
Results: Visual observation showed that by llth day post wounding the recovery was 75% approximately with Aloe Vera extract application, 50% and 30% was observed with mixture application and Xylo Aid respectively
Conclusion: Aloe Vera application for 11 days on rabbit skin wound showed better healing process in comparison to mixture and Xylo Aid
ABSTRACT
The use of ashes as a natural medicine for wound healing was evaluated in surgically induced wounds in the rabbit skin wound model. Ashes were prepared from dried buffalo dung, wood, and charcoal and their contents were analyzed with atomic absorption spectrophotometry. Each type of ashes was used as an experimental application on surgically induced skin wounds in the rabbit; an antibacterial ointment was used as a control. The healing results were evaluated over approximately 13 days. Consistent healing was observed in all the experimental wound sites, which was comparatively more rapid than the control wound site. The healing was deemed complete on eleventh day only with charcoal ash whereas for dung-cake ash and wood ash, the completion time was approximately 13 days. Ashes have unique properties to influence and enhance safe and sepsis-free wound healing in the rabbit skin wound model